The Jaguars are at the heart of the next step in the NFL's incursion into London as the team owned by Fulham owner Shahid Khan have committed to play one game here each season until 2016.
The goal is to build a steady fan base on this side of the Atlantic as the NFL continues to test the waters for a possible franchise, but Bradley conceded UK fans deserve a better product than his winless Jaguars - now 0-8 on the season - offered on their Wembley debut Sunday night.
"We've got to get things right," he said.
"Our mindset is to keep building and get to the point where we come back here and give London a team fighting for a play-off spot.
"It's been a really good week, the support we've had, it felt like the whole city bent over backwards for us."
Sunday's loss capped a tragic few days for Bradley, who only joined up with his team in London on Wednesday following the death of his father.
He could not find any relief in football as his team gave up four touchdowns in the opening 23 minutes to fall into a hole from which they would not recover.
San Francisco running back Frank Gore ran in the first score before quarterback Colin Kaepernick accounted for three, one in the air and two on the ground for a dominant 49ers team who showed why they had reached the Super Bowl last season.
"We talked about it a lot this week, we had to go in fast," said 49ers offensive tackle Joe Staley.
"We were going against a team looking anywhere for a win. You look for everything to go your way early and build from that.
"We had to let them know we came to play and we weren't overlooking them."
The Jaguars managed to break the shutout with a field goal 15 seconds before half-time and parlayed the momentum into a Mike Brown touchdown late in the third quarter, but San Francisco responded with two more touchdowns to kill them off.
"We came out in the second half and established some rhythm but it was too late, we were down 28-3 at that time," Bradley added.
The win lifted San Francisco to 6-2 to keep them firmly in the play-off picture, but the Jaguars are looking increasingly desperate for a win.
Running back Maurice Jones-Drew, one of their few outstanding players, insisted heads would not drop.
"I feel like every week we have a chance to win, and if you don't go into a game thinking that then you don't need to be playing football," he said.
"No one is hanging their head. We're going to continue to work so we can come through the losses and the adversity because when we turn this around it will make it that much better knowing how far you've come."