Paul George put up 29 points - nine of which came from three pointers - and 11 rebounds for the Pacers who moved to 22-14 after winning 11 of their last 13 matches.
David West added 14 points and 11 rebounds, and Lance Stephenson chipped in with 13 points, while Dwyane Wade scored 30 points and James had 22 points and 10 rebounds for the Heat who despite the loss have the best record in the Eastern Conference with 23-11.
Houston Rockets picked up their fifth straight win after they beat the Los Angeles Lakers 125-112, with James Harden leading the way.
Harden scored 31 points, while Chandler Parsons added 20 as the Rockets moved to 21-14, while the Lakers slipped to 15-19.
Metta World Peace had a season-high 24 points, while Kobe Bryant scored 20 and Steve Nash 16.
Nikola Pekovic led Minnesota Timberwolves to a 108-103 win over the Atlanta Hawks.
The Montenegrin picked up 25 points an a career-high 18 rebounds, ably assisted by Andrei Kirilenko's 21 points as the Timberwolves snapped an 11-game losing streak against the Hawks which stretched back to 2006.
Jim Boylan's first match in charge of the Milwaukee Bucks ended in victory as they beat the Phoenix Suns 108-99.
Boylan had only been the coach for a day after the Bucks parted ways with Scott Skiles on Monday but saw Brandon Jennings score 29 points as Milwaukee took advantage of the Suns poor recent form, with Alvin Gentry's side losing nine of their last 10.
Goran Dragic scored 21 points and Jared Dudley added 18 for Phoenix who are now 12-24
Elsewhere, Interim head coach P.J. Carlesimo picked up his sixth victory as Brooklyn Nets beat the Philadelphia 76ers 109-89. Reggie Evans registered a career-high 23 rebounds, while Deron Williams scored 22 points