Dwight Howard led the way with 23 points and 18 rebounds as the Lakers moved to 2-0 since Mike Brown was fired on Friday.
Wayne Ellington scored a career-best 25 points off the bench, including seven three-pointers, as the Memphis Grizzlies beat the Miami Heat 104-86.
Rudy Gay also poured in 21 points as the Grizzlies improved their record to 5-1, which constitutes their best start to a season in franchise history.
Chris Bosh led the Heat, whose four-game win streak was brought to an end, with 22 points while LeBron James had 20.
Russell Westbrook scored 27 points as the Oklahoma City Thunder beat the Cleveland Cavaliers 106-91.
The Brooklyn Nets were 82-74 victors over the Orlando Magic and the Los Angeles Clippers saw off the Atlanta Hawks 89-76.