Lopez collected 32 points and nine rebounds and Deron Williams added 24 and 10 assists for the Nets.
They won for the seventh time in eight games and bounced back from Saturday’s 32-point loss in Atlanta.
Thaddeus Young contributed 20 for Brooklyn (36-41), who are 1 1/2 games ahead of eighth-placed Boston in the Eastern Conference.
Damian Lillard led Portland with 36 points on 14-of-26 shooting and Meyers Leonard collected 17 and 15 rebounds, who lost for the second time in their last eight games in a match-up postponed due to a snowstorm in New York on January. 26.
The Trail Blazers, who clinched the Northwest Division on Friday, rested forwards LaMarcus Aldridge (left thumb) and Nicolas Batum (back) and center Chris Kaman (right thumb).