France head coach Guy Noves has made eight changes for the second Test against South Africa in Durban on Saturday.
With those Clermont and Toulon players from the Top 14 final available again, Scott Spedding takes over at full-back with rising star Damian Penaud named at outside-centre as he wins his first cap for France.
Baptiste Serin and François Trinh-Duc form a new half-back combination, while the one change to the back row sees Kévin Gourdon take the place of Loann Goujon at seven.
Romain Taofifeuna comes in to partner Yoann Maestri in the second row with the final two changes coming up front, where Rabah Slimani and captain Guilhem Guirado both start.
Bordeaux-Bègles back Nans Ducuing is the only other uncapped player in the matchday 23.
France: 15 Scott Spedding, 14 Yoann Huget, 13 Damian Penaud, 12 Gaël Fickou, 11 Virimi Vakatawa, 10 François Trinh-Duc, 9 Baptiste Serin, 8 Louis Picamoles, 7 Kévin Gourdon, 6 Yacouba Camara, 5 Romain Taofifeuna, 4 Yoann Maestri, 3 Rabah Slimani, 2 Guilhem Guirado (c), 1 Jefferson Poirot
Replacements: 16 Clément Maynadier, 17 Eddy Ben Arous, 18 Uini Atonio, 19 Julien le Devedec, 20 Bernard le Roux, 21 Antoine Dupont, 22 Jean-Marc Doussain, 23 Nans Ducuing
Date: Saturday, June 17
Venue: Kings Park, Durban
Kick-off: 17:00 local (15:00 GMT)
Referee: Ben O’Keeffe (New Zealand)
Assistant Referees: Glen Jackson (New Zealand), Angus Gardner (Australia)
TMO: Rowan Kitt (England)