The world number two meets Fernando Verdasco at the last-eight stage on Wednesday, and the Spaniard will be the first left-hander Murray has played in 2013.
The Scot, who has never reached the final four without dropping a set, has a perfect record so far this fortnight.
He warmed up at the Aorangi Park practice courts by hitting on Tuesday lunchtime with left-hander Johan Brunstrom, a Swedish doubles specialist, who was recruited by Murray's best friend and coaching team member Dani Vallverdu.
There were concerns on Monday about Murray's back during his win over Mikhail Youzhny, with the 26-year-old clutching at his side a number of times in an echo of the claycourt troubles that ended with him pulling out of the French Open.
Murray wore a tight undershirt again on Tuesday, which might have been a sign that he is having to nurse his back more now than earlier in the tournament, but he again denied it is a problem.
"The back's fine," he said.
One aspect that should help Murray is that, like his main title rival Novak Djokovic, he has eased through to this stage, but he would take any kind of win against Verdasco.
Murray said: "You just try to win whichever way you can. Three sets is obviously better because you save some energy but at this stage of the tournament you just try to win as quickly as you can."
Murray has flown a little under the radar by his standards so far, overshadowed during the first week by injuries and upsets and then by the progress of Laura Robson.
But Robson's fourth-round exit means for the sixth year in a row it is Murray who carries home hopes into the last eight.
He rated the pressure on his shoulders at the moment as "seven or eight" out of 10, saying: "Playing at the latter stages of grand slams is what you play the game for, and that's where there's the most pressure, so it builds with each match.
"I think all the matches are going to keep getting tougher. Everyone is going to be more comfortable with the conditions than they are at the beginning of the week.
"You don't fluke getting into the quarter-finals of a slam. You need to win four tough matches to get there. So everyone is playing well now, and it's going to keep getting tougher."
Verdasco is ranked only 54th in the world but was in the top 10 for much of 2009 and 2010 and has beaten quality players to get to the last eight.
Murray put his head in his hands when told that one pundit, former British Davis Cup player Barry Cowan, suggested he would have been happy at the start of the tournament had he known he would be facing Verdasco at this stage.
"Verdasco is a very, very good tennis player," said Murray. "He's playing very well this week. He's extremely dangerous when he's on his game."
That is undoubtedly true. The Spaniard has an excellent serve and a big forehand but is certainly not as daunting an opponent as Jo-Wilfried Tsonga, who Murray had been seeded to meet in the quarter-finals.
Murray also has a good record against left-handers, something he attributes partly to having played so much with brother Jamie when he was young.
He said: "I think it's pretty amazing six months into the year (not to have played a left-hander).
"I don't normally mind the way the ball comes off the racket from the back of the court. I grew up playing with my brother so that almost feels a bit more natural to me than a righty. But the serve is what's different and the way you move on the return."
A glance at their head-to-head record implies there is not too much for Murray to worry about, with the Scot having won eight of nine previous meetings against Verdasco.
But in grand slams they are tied at one-all, both at the Australian Open, with Verdasco winning the most recent one over five sets in the fourth round in 2009.
At that stage he looked a rising star of the game and went on to push Rafael Nadal in an epic semi-final in Melbourne.
Verdasco qualified for the ATP World Tour Finals in London that year - the last time he played Murray was at the O2 - and reached a career-high ranking of number seven.
But over the last three years Verdasco has fallen down the standings, and there was nothing in his results this year to suggest a renaissance was on the cards.
This will be the 29-year-old's first Wimbledon quarter-final and his first at any grand slam for almost three years.
Murray said of Verdasco's slide: "(I'm) a little bit (surprised). I lost to him at the Aussie Open a few years ago in the fourth round. He went on to have that great match with Rafa there. He was playing unbelievable tennis.
"He can play well on all the surfaces. It's just the consistency hasn't been there.
"It isn't easy to stay at the top of the game for a long time. It takes a lot of concentration, hard work and focus, also a bit of luck as well.
"He's had a few injuries. He's changed rackets quite a few times. That will have had something to do with it."