The 18-year-old from Illinois impressed on Tuesday as she defeated Heather Watson and, while British fans may not admit it, saw off a better player than the home hope in the form of the 30th-seeded Mona Barthel.
The German was able to live with Keys in the early exchanges but once she was broken by a crunching mid-range forehand in the fifth game, she was always up against it.
Keys staved off a break-back point as she served out the opener 6-4 and then enjoyed further success in the second to take it 6-2 and progress to a meeting with either the fourth-seeded Agnieszka Radwanska or Mathilde Johannson.
The US prospect has now equalled her best-ever return at a grand slam having made the third round at the Australian Open in January, making good on the promise she first showed when winning a match on the WTA tour aged just 14.
Keys is not the only young gun to have made an impact in the women's draw this week either, with the likes of Eugenie Bouchard, Monica Puig, Laura Robson and Sloane Stephens all under 21 and all impressing.
Keys has no answer as to why they are all graduating as threats at once, though, saying: "I don't really know why. I just think everyone has been working really hard and it all seems to be clicking right now."
The names of Bouchard and Robson have been well known for some time to those who follow tennis closely, but they were not necessarily earmarked to be the ones who would make the grade.
"It's kind of surprising," Keys said of her fellow teenagers' rise.
"I know Laura did well and I know Genie has done well, but they never dominated the juniors or anything like that.
"In a way it's surprising, then at the same time I think you look back and see the ones who were number one in the juniors and they are not always the ones who make it into the pros."