When Williams takes her seemingly invincible game out to Court One for a second-round meeting with Caroline Garcia, she will do so with the knowledge the most obvious threat to her title chances has been eliminated.
Sharapova tripped and tumbled her way out amid the storm about the state of the Wimbledon courts, meaning the pair will not be able to settle their off-court differences of recent weeks on the grass.
That is unlikely to bother merciless winner Williams, who has been doing nothing other than taking care of her own affairs.
"I'm just here to focus on the tennis," she said. "I'm here to play Wimbledon, the premiere tournament in the world, of the year. That's what's most important."
Sharapova felt the same until she ran into Portugal's Michelle Larcher de Brito and came out of it with a 6-3 6-4 loss.
Until now, Larcher de Brito has been best known for her loud high-pitched screech, leading to ridicule and scrutiny from many.
"It wasn't fair because people blew it way out of proportion," Larcher de Brito said. "But it's behind me.
"I don't want to talk about it anymore. It's over and done with. It's already an old topic, the grunting. People keep going on and on about it."
Sharapova's departure and the exit of Victoria Azarenka to a knee injury means that Williams is an even heavier favourite than she already was.
One bookmaker has her as a 2/9 shout to keep her title, with Petra Kvitova her most-fancied rival.
Stranger things have happened in sport, though, and the draw is starting to open up for one of the lower-ranked players to make a run through.
Great Britain's Laura Robson will be hoping she can be that player and she meets Mariana Duque-Marino on Court Two, while two other teenagers - Robson's best friend Eugenie Bouchard and Puerto Rican Monica Puig - also won.
Bouchard made the most of a late switch to Centre Court in just her second grand slam and beat the 12th-seeded Ana Ivanovic 6-3 6-3, while Puig got the better of Silvia Soler-Epinosa. The 20-year-old Sloane Stephens also made it through.
Among the others in action are the fourth-seeded 2012 runner-up Agnieszka Radwanska - she takes on Mathilde Johansson on Centre - and Li Na who face Simona Halep.