The world number two was a comfortable 6-3 6-3 7-5 winner but needed to save three break points in the early stages on Court One.
Seven players either did not start their singles matches on Wednesday or withdrew during them, including Victoria Azarenka, Jo-Wilfried Tsonga, John Isner, Marin Cilic and Rafael Nadal's conqueror Steve Darcis.
Caroline Wozniacki and Maria Sharapova also both slipped over as they tumbled out of the tournament and Murray approached Court One with a certain trepidation.
He said: "You have to concentrate on yourself but I think when a lot of players get injured, the one thing is you may be a little tentative at the beginning of the matches, maybe not feel that comfortable throwing yourself around the court.
"Maybe that's what it was just at the beginning. After the first few games, I felt fine."
The All England Club has come under fire after some players criticised the state of the courts, although its chief executive Richard Lewis insisted the grass is no different to the same stage last year.
Murray was inclined to see it as a freak day, saying: "Sometimes it's coincidence. Sometimes it can be footwear. Sometimes a bit of bad luck. Sometimes it can be the court surface. But I have no idea. I haven't seen all of the injuries that people have had.
"No one has said anything to me really in the locker rooms or anything about the courts being an issue. And I've felt fine in my matches so far."
Murray added of his experience on Court One on Wednesday: "Court One and Centre Court always play a little bit differently.
"Court One is a little bit quicker than Centre Court, and it's a lot more open. There's a lot of space at the side of the court. But it didn't feel different to previous years."
A dramatic day saved the most dramatic moment for last, with Sergiy Stakhovsky sensationally upsetting Roger Federer.
It was the defending champion's first loss at a grand slam before a quarter-final since the French Open in 2004, and his earliest at Wimbledon for 11 years.
The bottom half of the men's draw, which looked so daunting, has undoubtedly opened up for Murray even though it is only the third day of the Championships.
With Federer and Nadal, who were scheduled to meet in the quarter-finals, gone as potential semi-final opponents and Tsonga cleared from Murray's quarter, it is tough to see the second seed losing before the final.
However, Murray's message was clear - no one in the draw should be underestimated.
The 26-year-old said: "Everybody was so obsessed with how the draw was before the tournament started. Now everybody wants to change their views on it because a few guys have lost.
"There's top players still left in the tournament, and there's a lot of young guys as well coming through, guys like (Ernests) Gulbis, (Jerzy) Janowicz. Those sort of players are starting to break through and play more consistently.
"I'll just concentrate on my next match. I'm playing a tough player, a very experienced guy. I'll worry about that match."
Next up for Murray is 32nd seed Tommy Robredo, and if the Scot plays like he did against Lu it is a match he should come through.
Lu beat Andy Roddick to reach the quarter-finals here three years ago and handed Murray one of his more painful defeats in the first round of the Beijing Olympics in 2008.
He beat James Ward in round one to thwart hopes of an all-British clash, but he appeared to have little in his game to worry Murray.
Lu began confidently and forced three break points on the Murray serve in the fifth game but could not make a return on any of them.
Murray held and that proved the key moment as he then broke straight away, and an early break in the second set was enough.
Lu hung on doggedly in the third set in the face of real pressure, with Murray's forehand looking in particularly fine fettle.
The Chinese Taipei player, ranked 75th in the world, saved one match point at 5-4 behind with a big serve but he could hold out no longer two games later, sending a backhand long on Murray's third match point.
Murray said: "I think it went pretty well. He started off pretty well and he had a few break points. Then when I saved them, I started to settle down a bit, and he made a few more mistakes.
"But the third set was high quality. I was putting a lot of pressure on him, and he kept coming up with some good shots on break points and stuff like that. So I did well to finish it in three sets."