The world number 36 was coming off three straight first-round losses on clay but showed on the Sussex coast that grass is more to her liking as she beat American Jamie Hampton 6-2 6-1.
The resounding win, in one hour and 16 minutes, was defined by Vesnina's ability to capitalise once she got into position to break serve.
Qualifier Hampton, who faces a mouthwatering Wimbledon first-round clash against compatriot Sloane Stephens, could not build on her impressive semi-final victory over former world number one Caroline Wozniacki, but it was not for the lack of opportunities.
She had five break chances against the Vesnina serve, but the 23-year-old squandered them all, whereas her 26-year-old opponent seized on four of seven openings.
The eventual crushing margin of victory allowed Vesnina to get her hands on a trophy that has been previously won by some of the biggest names in tennis, including Martina Navratilova, Monica Seles, Lindsay Davenport, Justine Henin and Kim Clijsters.
Her first title of the year, gained in Hobart in January, was also the first of Vesnina's 11-year career.
Vesnina has been as high as 24th in the rankings in the past, and could soon improve on that. The two titles in 2013 have lifted her from 69th at the start of the year to a position where she is threatening to earn a seeding for the US Open later this year.
She will begin her Wimbledon campaign against Czech world number 95 Andrea Hlavackova, in their first career meeting.
Vesnina will equal her career-high ranking when the list is updated on Monday, and she said on www.wtatennis.com: "Maybe my time has come.
"Maybe I've changed a little bit as a player, as a person. I grew up. I started to be more mature. Maybe I know what to do in finals now, because before, even when I was losing those finals, I was playing against really good players, top-10 players most of them.
"But I kept believing in myself. I knew I would win this title. I knew it was going to happen. It's not self-confidence - I knew if I kept working hard and believing in myself, it would come. And it did."
It has been a stellar week for Hampton, even if it did not end the way she would have wanted.
The 23-year-old said: "I have given myself a two-hour time limit to sulk, basically the journey up to Wimbledon. I can sulk during that and maybe have a little chocolate, and then move on and get on with Wimbledon."
The men's title went to Feliciano Lopez, who gained considerable confidence for his first-round match at Wimbledon on Tuesday by beating second seed Gilles Simon 7-6 (7/2) 6-7 (5/7) 6-0.
By a quirk of fate, the two men will play again at the All England Club after being paired together in Friday's draw, making this final doubly significant.
Unusually for a Spaniard, Lopez is perfectly at home on grass and is a three-time quarter-finalist at Wimbledon.
Conditions were very tricky, with a swirling wind making life difficult for both players, but in the end it was Lopez who coped best, running away with the third set.
The victory gave the 31-year-old his third title on the ATP World Tour and his first for more than three years.