There were plenty of players like RafaeL Nadal still to complete second-round matches, and 19th seed John Isner came back from two sets down to win for the first time in his career.
His match against fellow American Ryan Harrison proved a Court Seven crowd pleaser, with the young pretender trying in vain to stave off Isner's fightback only to go down 5-7 6-7 (7/9) 6-3 6-1 8-6.
Isner said: "Just winning a five-set match is extremely satisfying as I exited every grand slam last year in five sets."
Eighth seed Janko Tipsarevic almost found himself in the same predicament but saw off Fernando Verdasco 7-6 (7/3) 6-1 3-6 5-7 8-6 while there were also wins for Richard Gasquet, Stanislas Wawrinka and 35-year-old Tommy Haas.
Meanwhile, in the third round, 10th seed Marin Cilic lost 7-6 (14/12) 6-4 7-5 to Serbia's Victor Troicki.