Currently undergoing cancer treatment, Hutchins will be part of the British Eurosport punditry team during the action at Roland Garros, which gets under way on Sunday.
He's part of a growing band of experts who are finding it hard to look beyond a woman who is the reigning Wimbledon, Olympic and US Open champion and who arrives at Roland Garros on a career-best 24-match winning streak. having won in both Madrid and Rome.
"I see this as down to Serena," Hutchins told sportinglife.com.
"I don't think anyone can compare to her. You have to remember she's won 15 Grand Slam singles titles. We always hear about Roger Federer's 17 but not so much Serena's total.
"I can't stress how good she is."
However, Williams did arrive in Paris in similarly good shape 12 months ago and duly lost to the lowly-ranked Virginie Razzano in the first round - the only time she has done so at a Grand Slam in her career.
"With the run she's on right now, she'll have to be mentally well below her best - as she was last year - to lose," added the GB Davis Cup star.
"I can't see anyone beating her if she has her game face on. She'll be going there thinking 'this is my title'. She's the firm favourite."
Defending champion Maria Sharapova, who triumphed in Stuttgart last month when Williams did not play, will be out to stop the American and Hutchins says she warrants respect.
He added: "Maria has improved a lot on the clay and has improved her serve immeasurably. She did very well there last year.
"It would be interesting to see how she deals with Serena as their matches have seen a lot of one-way traffic.
"If Serena gets over the first couple of rounds, she'll take some stopping."
Hutchins' fellow pundit Mark Petchey agrees.
Petchey, who will be in the rival ITV studio at Roland Garros, said: "She's got that winning streak and has dominance against the high-ranked players; I'm hard pressed to make a case for anyone else."
While the focus may well be on Williams come finals weekend, British eyes will largely on Laura Robson in the first week in Paris, especially with Andy Murray missing from the men's draw.
Petchey is confident of another strong showing from a player who made the third round at this season's Australian Open and the last 16 at last year's US Open.
"Laura's one to watch given the way she's played the last few weeks," he added.
"With her coaching change (she recently split from Zeljko Krajan) her general love of the game has re-emerged.
"Beating (Agnieszka) Radwanska in Madrid was a great result but she's got the power to go through Radwanska. Aga was slightly below her best as well but the confidence is there for Laura now and she's got a big game.
"As long as her serve holds up, I can see her in the last 16 and possibly even the quarter-finals."