In the battle between the top two players in the world, Williams needed just one hour and 18 minutes to see off the challenge of Sharapova, the American winning 6-1 6-4.
The victory improved the 31-year-old's hugely impressive career record against Sharapova to 13 wins from 15 matches, and also ensured the Russian could not claim top spot in the WTA rankings, which would have happened had Williams lost.
Williams had dropped just one set in the last seven meetings between the two and Sharapova looked unlikely to improve that record after she was broken three times in losing a one-sided opening set.
Sharapova, 26, did not manage to fashion a single break point in the first set - compared to five for Williams - but she improved in the second as she capitalised on one of her two break points.
However, that was not enough as Williams broke twice in reply to clinch the match and with it the 50th WTA title of her career - becoming only the 10th woman in history to reach the milestone.
Williams was determined to enjoy her latest title success, admitting she does not know how many more tournaments she might win.
She said on www.wtatennis.com: "It feels good. I don't know how many more I can win. Like I say every day, 'Who knows if I'll ever win another title?' I just want to live in the moment and the dream every chance I get."
Williams was sidelined from tennis for a year between 2010 and 2011 due to a foot injury and blood clots in her lung, and she added: "I feel like every moment I play - I don't know if it's because of what I went through - I feel like I'm so fortunate to be out there and healthy and to have an opportunity to play a sport and be really good at it.
"Hopefully I can just keep it going."
Sharapova conceded her poor start to the match had cost her dear.
"I started the match really slow today [Sunday], and against an opponent like her you just can't give her that because she plays extremely well when she's confident," said the Russian.
"I wasn't reacting well, I wasn't moving well - obviously not only the double faults that I made, but I also didn't have a lot of great first serves in. There were a lot of things I could have changed."