The home favourite, a finalist here last year and champion in 2008, had no answer to the on-song Spaniard's unerring accuracy and crashed out 6-2 7-5 in 80 minutes.
Sixth seed Tsonga gamely fought off two break points in his second service game but could not stop the Spanish juggernaut from taking the next four games.
The decisive break in the second set came in the 12th game when Ferrer, seeking back-to-back titles after triumphing in Valencia last week, wrapped up the win with his only match point after Tsonga miscued a forehand wide.
Tsonga may have the opportunity to gain revenge with both players qualifying for next week's ATP World Tour Finals while Ferrer, the highest seed left in the draw, will face Michael Llodra for a place in the showpiece event.
Llodra is the only Frenchman left in the draw after he battled past Sam Querrey 7-6 (7/4) 6-3.
The left-hander knocked out Juan Martin Del Potro yesterday and is yet to drop serve in his four matches this week.
Andy Murray's conqueror Jerzy Janowicz continued his spectacular run by ousting eighth seed Janko Tipsarevic to become the first Polish player to reach a Masters semi-final.
Qualifier Janowicz was leading 3-6 6-1 4-1 before his Serbian opponent withdrew citing illness - perhaps not wanting to worsen his condition with the World Tour Finals in mind.
Tomas Berdych can also start focusing on his preparations for London after he suffered an upset 6-4 6-4 defeat by France's Gilles Simon.
The Czech fifth seed opened up a 3-0 lead in the second set but Simon stormed back to take six of the next seven games and claim his fifth win over Berdych from seven meetings.