The world number one has yet to taste defeat in 21 matches this season and was on top form yet again as she easily dispatched rival Radwanska at Indian Wells.
The victory, which took just over an hour to complete, sees Australian Open champion Azarenka equal Serena Williams' 2003 record of 21-0 to start a season.
The Belarusian has already won three titles this year and now has her sights on Martina Hingis' record 37-0 start to the 1997 season.
World No.1 Azarenka and world No.5 Radwanska met for the first time since the Pole publically admitted she had "lost a lot of respect" for her opponent at the recent Qatar Open.
Azarenka put any tension between the pair to one side in sensational style, reeling off 11 straight games to serve for a double bagel.
Radwanska avoided the ignominy with a break and followed it with a hold, however Azarenka swiftly closed out a hugely-impressive win.
The world number one won the first 11 games of the match before Radwanska finally got on the board.
"I had very good motivation because I knew she's a very good player," Azarenka told www.wtatour.com.
"I have to play a very good match and show excellent tennis to beat her. I was focused on every moment, every point and every ball I was striking.
"I really didn't think about the score, because there's really no point getting into that.
"I hope I was a good example of women's tennis."
In the semi-finals, Azarenka will face Germany's Angelique Kerber, who beat eighth seed Li Na of China 6-4 6-2.