One of the world number four's lowest moments of a generally impressive 2011 came in Indian Wells in March when he lost to Young, who was ranked well outside the top 100 at the time, in his opening match.
Murray, suffering from post-Australian Open final malaise, then followed that up with an equally disappointing defeat by Alex Bogomolov Jr in his first match in Miami before rediscovering his form in the clay season.
Asked if he was the sort of person who thought about revenge, Murray said, smiling: "Yeah, I do.
"I was in a pretty bad place around Indian Wells, Miami time. It was a tough, tough part of the year for me. It's not so much revenge against Donald, it's more for the situation I was in there and making sure that I can move on from that.
"Winning against Bogomolov in Cincinnati was very important for me. The match against Young won't be any different."
While it was a moment Murray will want to put behind him, the Indian Wells victory was a huge result for Young, once the great hope of American tennis written off as an under-achiever.
The left-hander won the Australian Open junior title in 2005 as a 15-year-old, at that stage the youngest to do so, and had already been playing on the pro circuit for a couple of years when he followed that up with the Wimbledon junior title in 2007.
A swift rise up the rankings was expected to follow and for a while all seemed rosy as Young broke into the top 100 later in the same year, after reaching the third round of the US Open.
But the teenager's progress abruptly stalled and then he started to go backwards as he struggled on the Challenger Tour, frustrated that his junior success was not being replicated.
Not until this year have signs emerged that Young, now 22, may be ready to live up to his potential, with the American consistently winning matches and reaching the semi-finals at an ATP World Tour event in Washington last month.
Reflecting on his victory over Murray, Young said: "At that point it was the biggest win in my career. It still is level-wise of an opponent and ranking-wise."
Of his chances of a repeat, he added: "Definitely it will be different. It's three (sets) out of five. It's at a slam. I don't think he had too much confidence coming to Indian Wells. He wasn't playing his best. But I'm playing well also."
Young is refreshingly honest about where his career went off course, no longer seeking to blame others and accepting it was his attitude that held him back.
"It was tough because I wanted to win," he said. "I was used to winning. When you're used to winning and you start losing, it doesn't feel good. Then I was looking at myself at 15 playing grown men 25 to 30.
"Even at 22 I would hate to lose to someone 15 - I would try a lot harder anyway. So it was a learning experience. I think those things I did helped me now. It's better late than never.
"There's a lot of things I can improve. I feel like you can always improve and never feel like you know everything, which was probably a big thing of mine. I felt I didn't need to work as hard as other people."
What was never been in doubt is Young's ability, which allows him to play with a variety somewhat reminiscent of Murray, who is well aware of the danger posed in front of a partisan crowd.
The fourth seed said of Young: "He's talented, so he can hit winners from all parts of the court. He comes forward pretty well, he volleys good, he's got nice feel around the net, and he's got quite easy power, which can be sometimes difficult.
"Guys look like they're not winding up to hit a big shot, and he can create quite a lot of power. He's got a big first serve when he goes for it, but he can be a little bit inconsistent, as well. He's flashy. He can get on a roll. He's tough."