Ranked 64th in the world, 26-year-old Somdev will face an uphill task to advance beyond the first round against the in-form Murray.
The dou's meeting at Flushing Meadows will be the first between the two.
The Indian's record this year is solid, with a run through qualifying to the third round in Indian Wells in March the highlight, while last year, he won the gold medal in the men's singles tournament at the Commonwealth Games.
His fighting ability and a liking for hardcourts should pose a few problems for Murray, who has again been placed in Rafael Nadal's half of the draw.
Mirza, who is coming to New York following a string of losses in first rounds and qualifiers since her comeback post Wimbledon, is also expected to find the going tough against Peer.