The 21-year-old had little difficulty against Anastasia Rodionova, despatching the Australian with a 6-2 6-1 victory on Rod Laver Arena.
Wozniacki drove home every ball with the ferocity more often seen deep in the second week of a major than the opening day.
It certainly proved the wrist injury she sustained in the Sydney International was no cause for concern.
Rodionova had her chances, and will rue a rash of errors which cost her dear.
She could have taken the first break at 2-2 in the opening set, but lost four successive points to allow Wozniacki to level and retain her serve.
The Dane stepped into gear in the following game to take the advantage at 4-2, and dominated from then on, winning the next seven games before Rodionova finally held serve again with a well-placed forehand down the line which almost brought the crowd to their feet.
But she faded in the final game as Wozniacki neatly wrapped up the match in just over an hour.
Afterwards she said: "It (the wrist) feels much better. I was a bit nervous before the match as I didn't really know what to expect but I am very happy with the way I felt out there.
"When I got into my rhythm and started to play more comfortably it paid off."