Chisora, 29, is a former British heavyweight champion and returned to winning ways when he stopped Hector Alfredo Avila in the ninth round last month, after he lost two high-profile bouts in 2012 against WBC heavyweight champion Vitali Klitschko and rival David Haye.
Wilder beat Harrison in the first round of their fight in Sheffield on April 27, with the former Olympic champion retiring afterwards.
The 27-year-old from Alabama will now return to Britain on June 15 to top the card at Frank Warren's Behind Enemy Lines event at Wembley Arena where he will put his unbeaten record on the line against the Londoner.
The victory over Harrison was Wilder's 28th, but Chisora believes the American's winning run is tainted by the level of opposition he has faced in his career to date.
"I'm excited, I needed something like this to happen," he said.
"Now we will just have to wait and see on the night. I saw him when he first came on the scene and I told my trainer he would be a great opponent for me one day.
"The problem with his 28-0, I wish Frank had done that for me, given me a couple of cab drivers to knock-out so I could be 20-0.
"But that was not my idea when I came on the boxing scene. I always told Frank I didn't want to fight nobodies, I wanted to fight great fighters.
"I like a challenge, basically. This is one of those great challenges and it is going to be a great fight for me. He isn't going to bring anything I haven't seen before. Has he boxed anyone with my style? I don't think so."
Although ruining Wilder's unbeaten streak could theoretically move him towards the head of the queue for a world title fight, Chisora remains solely focused on beating the reigning WBC continental Americas champion.
"For now we are just looking at this fight," he added.
"It is one of those fights that will be very exciting, especially at Wembley, so I can't wait."
Warren believes the fight is too close to call but feels Chisora is at his best when he has a true challenge in the opposing corner.
"This fight will be without doubt one of the fights of the year," he said.
"I like to see Dereck in fights, he made a comment about cab drivers but all fighters are different and have different mentalities.
"Dereck needs fights that make him rise to the occasion. He needs guys who are going to be there in front of him and he has picked up experience over the last couple of years.
"This is going to be a cracking fight, a really good quality heavyweight battle. Wilder is supposed to be the next big thing in America and we have managed to get him over here.
"You have got two guys who have come to fight and don't take a backward step and you can be assured the fans will have a delightful evening watching it.
"All of the fights (on the card) are basically 50/50 fights on paper, you can't get any better than that."
The June 15 event will also see Frankie Gavin face Denton Vassell for the British and Commonwealth welterweight championship and Liverpool duo Paul Smith and Tony Dodson square off for the vacant super-middleweight championship of Great Britain.