The sprinter will go head to head with former employers Team Sky, who will be led by compatriot Bradley Wiggins as the Tour de France champion chases general classification honours.
Cavendish, the 2011 Tour de France green jersey winner, will change Quick-Step Cycling's approach to the 21-stage race, which runs from May 4-26, according to the team's sport director Davide Bramati.
He said: "We start with a very good team built around Mark Cavendish. The presence of a pure sprinter such as Mark will change our approach to the race if we compare it with our last participations.
"In any stage where we have a possibility, we have to try to do our best to go for the win.
"The competition is fierce, but we can count on a good group. We believe in our team and we will be there to try to fight and win."
Belgian quartet Iljo Keisse, Serge Pauwels, Gert Steegmans and Julien Vermote, Italian duo Gianluca Brambilla and Matteo Trentin, Jerome Pineau of Italy and Poland's Michal Golas make up the rest of the team.