Mathews came out a surprise victor in Oldham last April, wrenching the British lightweight title from the popular Mancunian who was starting to make waves on the domestic scene.
This time it's Crolla who must go into his opponent's backyard at the Liverpool Echo Arena with revenge very much on his mind and the Commonwealth belt at stake.
And Crolla is excited at the prospect of gunning for revenge after initially mulling a drop down to super-featherweight.
"I really wish it was sooner, I found out just after Christmas and it was like a late Christmas present," he told Sky Sports. "I can't wait for it, to make up for last time and put things right.
"Now it's seen as a 50-50 fight, but back then I was favourite. I made mistakes and Derry capitalised on them, I learned a harsh lesson losing in front of my own fans."
Mathews was considered a fading force by many 12 months ago but he dropped Crolla for the first time in his career and despite appearing to the weather the storm and a serious cut, the referee ended it in the sixth round.
It was a pivotal, and devastating moment in the youngster's career but Mathews' experience proved crucial that night and Crolla is determined not to make the same mistakes.
"It's a case of lesson learnt and I can't let the same happen again," he added. "It doesn't effect me mentally now, it's just something I look forward to and I want it more than anything. It's the fight I most wanted and it's up to me to deliver now.
"I always say 'you might be as hungry but you can't be more hungry than me'. I want it so badly I'm giving it everything I've got.
"We both want that Commonwealth title and I'm sure we'll both go to great lengths for it, and that's what'll make a great fight for the fans."