The WBC middleweight champion manages the European super-bantamweight title holder and is backing the youngster to overcome arguably his stiffest test to date.
"We are very happy for this fight because it's going to be like a world title eliminator," said Sergio.
"Frampton is a very good fighter but he won't be able to live with Kiko for a long fight. Kiko is a true champ who has only a goal, to become a world champion.
"I have known Kiko for many years now. He works very, very hard and he is in tremendous shape for this fight. He is the main man in Europe in the super bantamweight division and he'll prove that in Belfast."