The coach has brought in Clermont Auvergne hooker Benjamin Kayser for his debut at the expense of Dimitri Szarzewski, while Morgan Parra comes in for Maxime Machenaud at scrum-half and Thomas Domingo replaces Yannick Forestier at loosehead prop.
Castres full-back Brice Dulin retains his place in the starting line-up for the contest at Stade de France despite picking up a thigh injury in last weekend's 39-22 win over Argentina.
Victory for France this weekend will ensure they remain in fourth place in the world rankings and therefore be among the top seeds for the 2015 World Cup when the draw is made on December 3.
France team: Brice Dulin (Castres); Wesley Fofana (Clermont Auvergne), Florian Fritz (Toulouse), Maxime Mermoz (Toulon), Vincent Clerc (Toulouse); Frederic Michalak (Toulon), Morgan Parra (Clermont Auvergne); Fulgence Ouedraogo (Montpellier), Louis Picamoles (Toulouse), Yannick Nyanga (Toulouse); Yoann Maestri (Toulouse), Pascal Pape (capt, Stade Francais); Nicolas Mas (Perpignan), Benjamin Kayser (Clermont Auvergne), Thomas Domingo (Clermont Auvergne)
Replacements: Dimitri Szarzewski (Racing Metro), Yannick Forestier (Castres), Vincent Debaty (Clermont Auvergne), Jocelino Suta (Toulon), Damien Chouly (Clermont Auvergne), Maxime Machenaud (Racing Metro), Francois Trinh-Duc (Montpellier), Yoann Huget (Toulouse)