Quigg and Munroe square off five months after their original bout ended in an anti-climactic technical draw when a clash of heads left Munroe with a cut which forced a premature finish.
They do so in the limelight of Hatton's much-hyped comeback, with the Hitman seeking redemption by taking on former welterweight champion Vyacheslav Senchenko at the Manchester Arena.
While Hatton's return to action will undoubtedly be fascinating, purists will be similarly intrigued by the crossroads fight between Bury's Quigg and Leicester southpaw Munroe for the WBA 'interim' super-bantamweight belt.
The winner will earn a shiny belt of debatable worth to strap around his waist but also, more importantly, open the door to fights with the likes of 'proper' WBA champion Guillermo Rigondeaux.
Quigg, 24, is just grateful to be appearing on such a huge stage - but admits it would be nice to steal the limelight.
"I can't think of anything bigger in boxing at the moment than Ricky Hatton's comeback so for my fight to be on the undercard is great," he said.
"The publicity I'm going to get through it being such a big event, I wouldn't have got that anywhere else.
"For people to say this fight might end up being the fight of the night is great.
"I think it could upstage Ricky's fight and it would be a great achievement to be in a fight such as that.
"It's going to be a cracking fight. Rendall is world class, he's fought at world level when he boxed for the WBC title and did so well.
"I'm getting in there with a world-class fighter on Saturday and the job I do on him and the way I win will show whether I'm ready or not. I'm confident I am ready to move onto big things in 2013."
Reflecting on their unsatisfactory three rounds in June, the Lancastrian said: "It's a disappointment for both of us how the last fight ended because we'd both trained hard but I'm just glad it's been made again.
"His eye has healed quickly apparently so it's a fight I'm looking forward to.
"I was feeling comfortable in the first fight, I saw things that were working for me but I'm expecting a better Rendall Munroe because I think he might have underestimated me first time around."
Munroe, who challenged Toshiaki Nishioka for the WBC super-bantamweight title in Tokyo in 2010 and gave a good account of himself, has shrugged off the fact many are tipping Quigg to win.
"Obviously they're looking at Scott Quigg as the young prospect rather than focusing on the quality of fighters I've boxed," said the 32-year-old former bin man.
"I don't watch others, I just do what I've got to do. It's been very frustrating for me because I proved myself as an elite athlete against Nishioka but I proved myself too much because since then, nobody will give me a chance."
A quality undercard also sees St Helens' former world title challenger Martin Murray bid to claim the WBA's 'interim' middleweight belt against Jorge Navarro while Gary Buckland defends his British super-featherweight title against Stephen Foster Jr.
European champion Sergey Rabchenko, who is trained by Hatton, defends his belt against Cedric Vitu.