Trump lost to Higgins in the final of the Shanghai Masters in September and UKPTC4 last week, as well as the 2001 World Championship.
But the 23-year-old from Bristol finally broke the Wizard's spell with a mesmerising display at the end of the first ever professional tournament in Bulgaria.
In winning the recent International Championship in China, Trump climbed to number one in the world rankings, and on current form looks determined to become snooker's dominant force.
Breaks of 47 and 42 gave him the opening frame and he took the second after Higgins crucially missed the third-last red along the top cushion when just six points behind.
Trump potted 11 reds with blacks in frame three, but when a maximum 147 beckoned, he missed the 12th red with the rest. But the left-hander barely minded as he wrapped up victory in the next frame with a run of 63.
"I have lost to John a few times recently so I really wanted to beat him," said Trump after capturing the 12,000 Euros top prize as well as 2,000 ranking points. "It was a great atmosphere tonight, the crowd were brilliant and I really felt as if I could play well.
"I have been in four finals now this season and I feel as if I can win every tournament I enter, as long as I don't have to play John. I have really enjoyed being in Bulgaria and I hope in the future they can produce some top players."
Higgins added: "I had a chance to win the second frame but I missed a red, and that was really the only chance I got. Judd played too well for me this time. I'm looking ahead to the next few tournaments now and hoping to have a good run in the UK Championship.
"The fans here have been amazing and it makes me want to come back."