The 41-year-old former WBC champion has been back in the ring for three years having initially hung up his gloves in 2007, but a route back to any semblance of glory will surely be closed off after this fifth-round stoppage against an impressive Anderson.
The weight of pressure got too much for Reid to handle and 15 seconds shy of the bell, proceedings were called to halt. He had signalled the end himself just seconds earlier, dropping to his knees for a count of eight following an innocuous right-hander from Anderson, who himself had retaken his guard, clearly placing no value on the shot.
The fifth round had hardly started well for Reid either, being docked a point for a third blow below the waist, and perhaps hinting at his reckless state of mind, he left himself wide open to Anderson after that.
Despite the seemingly soft nature of the shot that put Reid down, Anderson got the job done in style, loading up a number of combinations behind his unerring left-hand jab, although at the start of the night, such a slick ending seemed ambitious.
The two opened up with a lengthy hold that was only halted when they dragged each other to the floor, with Anderson, now 18-1-0, landing on top of Reid and taking some wind out of him early on.
But Reid ended the first with some good work to the body and Anderson started the second by making a breakthrough with his left-handed jab, getting through to Reid's face before catching the Runcorn man with a glancing left that rocked him back on his heels.
Reid's face was starting to redden around his left eye so he went on the offensive, landing a sweet left hook on Anderson's ribs, before swallowing up a right-left combination from the Scot.
His work to the body was skirting close to the edge, though, and he was warned for going below the belt, with a clearly riled Anderson landing the cleanest shot at that point - a left hook to the head - on the back of it.
Sensing an opening, Anderson went to the body in the fourth and then got through with another left, with Reid then being warned again for another low shot.
He would get away with it no more, though, losing a point in the fifth, although it mattered little as he was soon out of the running.
A straight right from Anderson appeared to have been absorbed until Reid, now 42-8-1, went to ground, and his ending came not long after that.