The popular Scot blew British rival Mitchell away in four rounds in Glasgow on September 22 with perhaps the best performance of his career.
He is now targeting high-profile unification bouts with the likes of American star Adrien Broner, but in the meantime he will have the chance to rack up a third defence of his WBO belt.
Burns will fight a 'top-10 challenger' at London's ExCel arena on December 15.
Burns said: "Since the win over Mitchell the response I've had from the Scottish fans has been fantastic, but I've also had so many congratulation messages from the English fans saying what a great fight performance it was and when am I coming to England to fight again.
"I didn't realise that it would be my very next fight so I'm happy to come down and give them a Christmas treat at the ExCel.
"The last couple of years have been fantastic with wins over Roman Martinez, (Michael) Katsidis and now Mitchell. I seem to be getting better and better as the challenges in my career step up each time.
"December 15 is another crucial date for me, once I get that out of the way I'm looking forward to some big unification fights in 2013."
Unbeaten super-middleweight George Groves and Commonwealth middleweight champion Billy Joe Saunders will also feature on the bill.