Les Bleus head to Cardiff looking to derail Welsh hopes of landing the Grand Slam and Saint-Andre has made six changes, the most notable of which sees 19-year-old Clermont back Jean-Marcellin Buttin called up for the first time.
Julien Pierre, Fulgence Ouedraogo, Dimitri Yachvili, Alexis Palisson and Florian Fritz were all named as Saint-Andre reacts to yesterday's 24-22 home defeat to England which ended France's title hopes.
Julien Dupuy, Maxime Mermoz, Julien Malzieu and Lionel Nallet all make way while Vincent Clerc has a shoulder injury. There are also injury doubts over Thierry Dusautoir (knee), Imanol Harinordoquy (knee) and Julien Bonnaire (elbow).
The France squad is: Forwards: J Poux (Toulouse), N Mas (Perpignan), V Debaty (Clermont), D Attoub (Stade Francais), D Szarzewski (Stade Francais), W Servat (Toulouse), P Pape (Stade Francais), Y Maestri (Toulouse), J Pierre (Clermont), T Dusautoir (Toulouse, captain), F Ouedraogo (Montpellier), J Bonnaire (Clermont), I Harinordoquy (Biarritz), L Picamoles (Toulouse).
Backs: M Parra (Clermont), D Yachvili (Biarritz), F Trinh-Duc (Montpellier), L Beauxis (Toulouse), W Fofana (Clermont), A Rougerie (Clermont), F Fritz (Toulouse), A Palisson (Toulon), J Buttin (Clermont), C Poitrenaud (Toulouse).