Matthews was fighting in his native Liverpool at the Olympia but he couldn't claim victory as the contest was halted after a barrage of powerful punches from Marsili.
The Italian has extended his unbeaten record to 24 fights with this impressive display.
"I thought I hurt him but he came back, he's a warrior," Matthews told Box Nation.
"My nose went in the first round, well, it went in sparring but I'm a Scouser and I love fighting.
"I'm not making excuses, I worked my b******* off. Marsili beat me."