It was confirmed last month that the CIRC would be chaired by Switzerland's former state prosecutor Dick Marty and would include Peter Nicholson, an Australian who has investigated war crimes for the United Nations, and German anti-doping specialist Ulrich Haas.
And at its first meeting of the year in Hoogerheeide, the UCI approved the regulations for the CIRC, saying in a statement: "It (UCI) approved the regulations under which the CIRC will operate.
"The regulations, effective for a year from 1 February 2014, cover all aspects of the CIRC's work including the procedures in place to enable it to offer reduced sanctions to people admitting to past doping offences whilst assisting the CIRC in its investigation.
"This follows the announcement in January of the composition of CIRC, headed by Swiss politician Dick Marty."
The investigation will centre on the UCI's dealings with doping findings and allegations during the late 1990s and early 2000s, including its handling of claims against Lance Armstrong who has since admitted to doping.
Brian Cookson, the former head of British Cycling who beat Ireland's Pat McQuaid in an election for the UCI presidency in September, said he wants the commission's investigation to be completed this year.
The key to the commission's success may hinge on whether Armstrong, McQuaid and Hein Verbruggen, UCI president at the time of the Armstrong's seven Tour de France wins, agree to give evidence.