The three-day event, which begins today, is the first time the World Cup series has taken place in Manchester since February 2011 after excursions to London and Glasgow.
Then the team included Sir Chris Hoy, Victoria Pendleton and Sir Bradley Wiggins and while none are riding this weekend, there will be seven Olympic champions in the British squad.
Three-time Olympic champion Jason Kenny said: "It's important to make use of home advantage if we can.
"Historically we've gone quite well at the Manchester World Cup and it does put you in a good place.
"We'll be keen to get stuck in and hopefully get a few medals out of it."
Kenny will ride in the team sprint on day one alongside fellow London 2012 gold medal winner Phil Hindes and Kian Emadi.
The corresponding women's event will feature Vicky Williamson and Becky James, who combined for Track Cycling World Championships bronze in Minsk in February.
The first final of Friday evening is in the men's team pursuit, an event in which Britain are Olympic champions.
London 2012 gold medal winners Ed Clancy and Steven Burke are expected to combined with 2012 world champion Andy Tennant and Owain Doull or Sam Harrison, with Jon Dibben expected to ride in the six-discipline omnium, which begins on Friday.
Burke is optimistic of a successful competition.
"I've been really impressed with the younger lads," Burke said.
"Morale's high and we're pretty confident we can come away with a good result."
The corresponding women's event now takes place with four riders and over four kilometres, like the men's, but Britain's supremacy remains.
Britain won five out of six world titles since the three-woman, 3km event was included on the World Championships programme in 2008 - 2010 being the exception - and the first Olympic title in the event in London.
London 2012 champions Laura Trott, Dani King and Joanna Rowsell are joined by Elinor Barker in Manchester, after Britain won the European title at a canter earlier this month.
Competition is anticipated to be tougher this weekend, but Britain are not concerned with the opposition and focused purely on themselves.
King said: "We're definitely going to go faster than we did in Apeldoorn and it's only going to get faster.
"We're going to learn the event and get stronger. We're such a young team as well, which works in our favour."