Scotland international Lawson moved to the Falcons from Irish earlier this year, but a broken finger delayed his debut until last weekend's Amlin Challenge Cup clash against Brive, when he scored a try.
And after being named in Scotland's squad for the autumn Tests earlier this week, Lawson's focus is now on helping Newcastle gain a first Premiership home win of the campaign following away-day successes last month against Sale Sharks and Worcester.
"I am itching to be involved. It was very frustrating to miss out at the start of the season," he said, ahead of Sunday's clash.
"But we started that first block of five games quite well, which is pleasing, and that made it a little bit easier.
"And this is where I wanted my family to be, closer to Scotland. In the end, when the opportunity came up, I had to take it.
"The Premiership is our main focus where we will be concentrating all of our energies. That is the competition we want to do well in, and ideally we would like to be chasing the top four and six, rather than looking over our shoulder.
"Two good away wins already this season is encouraging for the squad. Now, we have to try and find some good form at home.
"We want to make Kingston Road the toughest ground in the Premiership for clubs to come and play, and that starts this weekend."
Newcastle boss Dean Richards makes seven changes from the side beaten by Brive. Centre Danny Barnes is called up, while full-back Alex Tait returns after recovering from a virus, wing Tom Catterick replaces Sean Brown and Rory Clegg and Mike Blair team up at half-back. Experienced forwards Carlo del Fava and Ally Hogg also start.
Chris Hala'ufia returns to the London Irish back-row as one of several changes as the Exiles resume Premiership business. Hala'ufia packs down alongside Ofisa Treviranus and Blair Cowan, who was recently named with Lawson in Scotland's autumn squad.
Elsewhere on Sunday, Wasps - eager to start climbing the Premiership table from their current 11th position - welcome back Elliot Daly, Tom Palmer and Ashley Johnson to starting duties against Adams Park visitors Leicester.
"The players know that they are in for a tough challenge on Sunday afternoon, but after two good wins in Europe there is a lot of confidence going back into domestic action," Wasps rugby director David Young said.
"At this stage of the season the table can change overnight, and a win for us would see us shoot up the table.
"Both sides will be fighting tooth and nail for the points on offer, and we know that we will have to be at our most accurate to come out on top."