Ducati on Friday confirmed Crutchlow will ride for them in MotoGP from next season after signing a two-year contract with the Italian manufacturer, replacing American Nicky Hayden.
The move will bring an end to what will have been three years with Yamaha's satellite team, Tech 3, for the 27-year-old Coventry-born rider who currently lives on the Isle of Man.
Crutchlow had hoped for a factory ride with Yamaha, but found such a path blocked, primarily with those seats taken by Jorge Lorenzo and Valentino Rossi.
Crutchlow also learned Tech3 had lined up Moto2 title contender Pol Espargaro for next season to partner his current team-mate in fellow Briton Bradley Smith.
Looking ahead to the future, via his official Twitter account Crutchlow said: "So it's now official! I will ride for Ducati next season in MotoGP.
"I will do my best with this project and believe that I will have great support from a manufacturer and team that believe in me."
Crutchlow, currently enjoying his best season in MotoGP as he lies fifth in the standings after claiming four podiums in the last six races, has vowed to leave Tech3 on a high.
He added: "My Tech3 team have been absolutely amazing over the last 3years & I'll be very very sad to leave! Certainly give them my all rest of year."
Although finally gaining the factory ride he feels he deserves, Crutchlow is taking a gamble in joining Ducati.
Despite being backed by Audi following their acquisition last year, Ducati has yet to mount the podium this season with either Hayden or team-mate Andrea Dovizioso, with the team's last win back in 2010.
In announcing Crutchlow's move and Hayden's exit, a statement from Ducati Racing read: "Ducati has reached an agreement with Cal Crutchlow that will have the Briton campaigning the 2014 and 2015 MotoGP race seasons with the Ducati Team.
"Crutchlow will race alongside Andrea Dovizioso. The British rider and the Italian, who were team-mates in 2012, will work on developing the Desmosedici and growing Ducati's MotoGP project.
"The 2009 World Supersport champion and 2011 MotoGP Rookie of the Year, Crutchlow is presently enjoying his strongest GP season to date, sitting fifth in the championship points standings.
"He has posted four podium finishes in the first nine races, and he earned his first MotoGP pole position at the Dutch TT.
"The end of the 2013 season will also mark the completion of Nicky Hayden's five-year professional relationship with the Ducati Team.
"Ducati would like to thank Nicky for his contributions during that time, and everyone on the team and at Ducati Corse looks forward to giving him and Andrea their full support over the second half of the 2013 season."