Yamaha Factory Racing's Jorge Lorenzo, who endured one of his tougher races in recent times last time out in Texas, will be hoping to capitalize on the track's layout, which should be more favourable to his Yamaha M1.
However, all eyes will be on Repsol Honda Team's young charger Marc Marquez, who, two weeks earlier, became the youngest ever winner in the premier-class in only his second ever race. On the other hand, jis team-mate Dani Pedrosa, one of the pre-season favourites, will hope that his home support can rouse him sufficiently to record his first win of the season.
Monster Yamaha Tech 3's Cal Crutchlow, who put in one of the rides of his career in Austin, will aim to continue his podium charge, while competing with Yamaha's Valentino Rossi. The Italian suffered an issue with a chipped brake-disc in Texas but will be expected to bounce back as he looks for to find tge form that put him back on the map in Qatar.
LCR Honda MotoGP's Stefan Bradl has looked continuously fast in both preceding race weekends but will want to close in on the top riders while GO&FUN Honda Gresini's Alvaro Bautista will seek to overcome the setup issues that hampered his charge in the United States.
Tech 3's rookie Bradley Smith, like many others, is much more familiar with the Jerez track, which could allow him to climb up the rankings although he will have to battle it out with top Ducati Team duo Andrea Dovizioso and Nicky Hayden.
Ducati will be buoyed by the fact that during testing at the circuit, they had Michele Pirro running a full test schedule with three separate Desmosedicis and the 26-year-old will also be taking part in the race as a wildcard.
Meanwhile, Energy T.I. Pramac Racing's Andrea Iannone will be the only individual lining up for the team as Ignite Pramac's Ben Spies will have to miss out due to a reccurring injury.
The CRT field will have a big task on its hands in their bid to challenge the current dominance of Power Electronics Aspar's Aleix Espargaro. His team-mate Randy de Puniet is also edging closer, while NGM Mobile Forward Racing's Colin Edwards will hope to overcome his disappointment from retiring in his home race in Texas.
His team-mate Claudio Corti will aim to do battle with the impressive looking Yonny Hernandez on his PBM ART, while Michael Laverty, Avintia Blusens' Hiroshi Aoyama, Hector Barbera and Gresini's Bryan Staring are also expected to be in the mix lower down the order.
Came IodaRacing Project's Lukas Pesek and Danilo Petrucci will also be hoping for a turnaround in their fortunes after a crash and retirement respectively in Austin.
However, Cardion AB Motorracing's Karel Abraham will not take part in the race as he sustained a broken collarbone after a crash in Texas, and could be out for upto three to four weeks with an expected return in Le Mans.