The Repsol Honda rider dislocated his left shoulder on the morning of the last round at Silverstone but still managed to finish second in the British GP to extend his lead in the points standings.
Marquez was close to winning the Silverstone race and only gave up first place to defending champion Jorge Lorenzo when the factory Yamaha rider dived inside him at the final corner to take a dramatic victory.
But second place was enough to put Marquez 30 points ahead of team-mate Dani Pedrosa, who was third at Silverstone, with Lorenzo nine points further back.
But before setting his sights on victory at Misano Marquez has taken extra time to regain full fitness.
Marquez said: "I'm already feeling much better since my accident in Silverstone, so hopefully I'll be almost 100% by this weekend. I will arrive in Italy for the race weekend a little later than usual as I will use the time to have more physiotherapy on my shoulder."
British rider Cal Crutchlow will look to get his MotoGP challenge back on track as he could only finish seventh in his home race after crashing three times in practice ahead of the race.
Crutchlow has seen his fortunes reversed since it was announced he would leave the Tech 3 Monster Yamaha team to race for Ducati next season.
Fellow Briton Scott Redding has seen his results go in the right direction since revealing he would race against Crutchlow in MotoGP next season after signing a deal with the Gresini Honda team.
Redding won the Silverstone Moto2 race on the Marc VDS machine to increase his lead in the championship standings to 38 points over Spaniard Pol Espargaro.
Redding said: "To win at home and extend my championship lead was a great feeling, but it's back to work this weekend."
Redding, who has just spent two days testing at Vallelunga in Italy, added: "The goal has to be to fight for a podium at Misano and, if possible, try and finish in front of Pol to extend my lead in the championship even further."
In the Moto3 class Spain's Luis Salom holds a 26-point lead on the Red Bull KTM going into Misano.