Lorenzo heads into Sunday's Malaysian round at Kuala Lumpur's Sepang circuit with a 28-point lead over nearest rival and fellow Spaniard Dani Pedrosa.
Honda's Pedrosa, however, is on a hot streak after winning four of the last five GPs, with his one blemish a first-lap collision in the race in San Marino last month.
Lorenzo, however, has finished second to Pedrosa on each occasion, and knows he can afford to maintain such a run over the final three races and still win the championship such is his cushion.
With one title to his name from 2010, factory Yamaha star Lorenzo is unruffled as he said: "For me this year is quite different.
"Two years ago I was still chasing my first title, so I was a little bit more nervous and I had to take more risks because I had to secure a first title.
"Now that I have already won a title, at least I can be happy with winning it once, even if the goal is to get more titles.
"Thinking about it, not so many riders have a title so now I can take things a bit more calmly."
Rather than getting riled by his failure to win races, Lorenzo has also learned to appreciate he can do nothing but simply give his all in light of Pedrosa's performances.
Speaking to motogp.com, Lorenzo said: "Since Laguna Seca, Dani and his bike proved really strong and for us it's harder to beat him on a regular basis compared to the early stages of the season when we were able to build a solid lead in the championship.
"Now it's more complicated, but things change, so you have to keep a global perspective on the season and there's no point in going crazy about winning races when you know you can't.
"I tried but couldn't win the last two races, but I might be able to win the next two. If I can't I'll just have to make sure I finish as high as I can."
The MotoGP paddock, meanwhile, paid its respects to Marco Simoncelli who lost his life in last year's race at Sepang.
Fausto Gresini, owner of the San Carlo Honda Gresini team for which Simoncelli rode, placed a permanent plaque at turn 11 where the Italian suffered his fatal crash.
With hundreds in attendance, a round of applause was followed by a two-minute silence as a mark of respect for Simoncelli.
Fellow Italian and seven-times champion Valentino Rossi said: "It was very emotional.
"It's already one year, but when these things happen it's difficult to understand the time.
"It's always like the first day. During a normal day, especially in the paddock, we miss him a lot."