Kristensen, together with Britain's Allan McNish and Frenchman Loic Duval, took the chequered flag at La Sarthe to bring an end to a race that will be forever overshadowed by the death of Aston Martin driver Simonsen - the first racing fatality at Le Mans in 27 years.
For Kristensen, the loss of his compatriot and friend will only compound the sense of grief he already felt following the death in March of his father, Carl-Erik Kristensen, a former racing driver himself who mentored his son's hugely successful career.
Kristensen revealed his father predicted he would claim his first Le Mans win since 2008 this year - but the 45-year-old admitted there was only one man to whom he could dedicate this latest victory.
"I'm very humbled to drive for the best team in the world," said Kristensen. "This is a dream come true, winning the toughest and fastest race in the world.
"But we lost somebody yesterday [Saturday] who had the same dream as well and was an absolutely humble and nice guy, so it's mixed feelings.
"If we talk personally about my Le Mans victories, I drive with my father's determination, with his ambition. He died in March, and he said I'd win Le Mans this year.
"So I hope there will be another race one day so maybe we can win another one and dedicate it to my dad - because this one is for Allan Simonsen."
GTE Am competitor Simonsen, 34, died on Saturday when his Aston Martin came off the track in Tetre Rouge and hit the barriers at high speed on the fourth lap of the race.
Race organisers said an investigation was focusing on the possibility that the accident occurred "due to circumstances in the race".
Onboard footage from the car following immediately behind Simonsen at the time of the crash appears to show another competitor further down the road going off the track in a separate incident just seconds earlier.
Simonsen's death inevitably diluted interest in battle for victory, which nevertheless was as hard-fought as ever, and played out against the dramatic backdrop of a record 11 safety car periods and a rash of heavy downpours.
Yet in the final analysis the result was a very familiar one, with the ultra-slick Audi operation claiming a fourth win in succession, and 12th in the last 14 years.
The result marked McNish's third Le Mans triumph while Duval enjoyed his first taste of the victory at La Sarthe at the fifth attempt.
Speaking to Press Association Sport after the race, 43-year-old Scot McNish likened the loss of seven-time Le Mans veteran Simonsen to that of a brother.
"We're racing drivers. We all grew up with a passion and a skill and we do what we love. We all know that something can happen, especially in races like this," he said.
"It's a close community and each driver in a way is like your brother because you share of the same feelings and emotions.
"Denmark is a small country, and Tom is a leader of the Danish drivers, so therefore if you've been team-mates with Tom for a long time, you know all the Danish drivers.
"It was a tragic loss, an absolutely tragic loss of someone who has so much talent and was so young.
"He was doing what he loves doing and he had a lot of career behind him, but unfortunately had a lot of career ahead of him as well."
McNish was at least able to take some enjoyment from his latest Le Mans success, which follows on from wins in 1998 and 2008.
Asked how it felt to be a three-time winner, he replied: "Much better than two-time winner!
"It's a fantastic feeling to have won this race, which had such high drama. Right from the word go it was a very difficult one with the weather, so you had to be very delicate.
"I was very sure in my mind that the race was going to be won by not having any mistakes."
McNish was joined on the podium by two fellow Britons.
Anthony Davidson - racing alongside Sebastien Buemi and Stephane Sarrazin - claimed his best result at Le Mans as the number eight Toyota came home in second place, while Oliver Jarvis - together with Audi team-mates Marc Gene and Lucas di Grassi - celebrated his second successive podium in just his third Le Mans outing.