Given Schumacher's relationship with Brawn over many years, winning seven world titles together - two at Benetton and five with Ferrari - the former's exit was always going to be tough to bear.
That is despite the fact that after stepping back out of retirement at the start of 2010, his three years with Mercedes were but a pale shadow of the success he enjoyed prior to hanging up his gloves for the first time.
Brawn concedes Hamilton's arrival, however, has had a galvanising effect on the team as the Brackley-based marque starts a new era and attempts to find glory.
Speaking ahead of the opening grand prix in Melbourne this weekend, Brawn said: "When someone of the status of Michael leaves the team that's a very big hole to fill.
"At the moment Lewis is filling it perfectly, but in his own style, his own way. I don't want a clone of Michael. We want someone who does it his own way.
"Lewis' performance, and very importantly his natural status within the team, the way he works with people and the direction he can give you, he can carry out that task in his own way.
"But he's brought quite a fresh buzz to the team in the way he has approached things, the way he is working with the engineers, and I must say I'm delighted with the way it has gone so far.
"We've not yet been in the white heat of battle because when you go racing you learn a lot more about your drivers, their relationship and how that develops, so that's to come.
"But in testing it went as well as I could have expected, not only on the track, but in terms of the working relationship Lewis is building with this team, and with his team-mate (Nico Rosberg).
"There is a vital relationship there, and I'm sure it will have its moments because they're two very competitive guys.
"We want them to be competitive, they have to beat each other, but they need to do it in a way that's constructive for the team and takes the team forward.
"So far it's been very encouraging, and a real motivation and a buzz for the team to be working with Lewis."
New motorsport director Toto Wolff, who only joined the team a few weeks after Hamilton's own arrival at the start of the year, has also swiftly recognised the impact made by the 28-year-old Briton.
"He is a very inspiring personality. It was interesting to meet him," said Wolff.
"You can see the difference between the good ones and the very good ones, but not only is he very talented, he is also intelligent and has settled in well with the team.
"He has a big social intelligence, he is building alliances. He's a great guy."