The circuit is one of the most challenging and highly-anticpated tracks in the Formula 1 calendar.
But it is one that has eluded Vettel so far.
The Red Bull driver and reigning world champion did come close last year, finishing second behind winner Fernando Alonso.
Looking ahead to this weekend's race under the lights, Vettel hopes to end his duck at The Marina Bay Street Circuit and is relishing the challenges it pose.
"We've had some good races in Singapore in the past, especially last year when we finished second, just behind Fernando," he was quoted as saying in the official F1 website.
"I love the track, it's very challenging; there are a lot of corners, it's very long, it's hot and it's a night race, so there are a lot of special things about Singapore.
"The car seems to be very competitive there, so I hope we can go back there this year and win - it would be very special.
The German could all but seal the drivers' title for the second year running with a win in Singapore.
But he is keeping his feet on the ground.
"Looking to the Championship, there is still some way to go. We are in a very strong position, which we deserve because we've been working hard and made few mistakes.
"As long as we come out of the next race with a bigger lead then we start with, then we have done a good job, so let's see."