For four successive years Red Bull and Sebastian Vettel have crushed the opposition by clinching the constructors' and drivers' titles.
Newey, as chief technical officer, has been the architect behind the triumphs, designing cars that have won 39 of the 75 grands prix so far over that four-year period.
But with the advent of new regulations for next season, with turbo-charged 1.6-litre V6 powertrains replacing the current 2.4-litre V8s, the emphasis switches to the engine manufacturers and away from the teams themselves.
To that end, Red Bull will be relying on Renault to keep them ahead of Mercedes and Ferrari especially, along with Lotus (also supplied by Renault) and McLaren (supplied by Mercedes).
"It's very hard to judge where we'll be at the start of the year," said Newey.
"The regulation changes are engine dominated and it's not at all clear at the moment which of the three manufacturers will come up with a better product than the other two.
"That's both from a performance point of a view and reliability, which will certainly be quite a concern at the start of the season.
"The new regulations for the power unit are massively complicated for the engine manufacturers themselves.
"It's also very complicated for us - the chassis manufacturers. It's a very complicated installation which the mechanics won't take an instant liking to, probably."
For Newey, that at least allows him to flex his design muscles again, offering him a different challenge compared to recent years.
He added: "We've got some quite significant aerodynamic regulation changes, not nearly as big as the ones we had in 2009, but still by normal year-to-year standards very big changes."