On the back of failing to qualify in the top 10 for the first time in 67 races on Saturday, Hamilton's Italian Grand Prix plans went out of the window at the first chicane.
Not only was his radio not working, and which failed to do so for the entire 53-lap race, but Hamilton's Mercedes collected a slow puncture after Lotus' Kimi Raikkonen ran into the back of McLaren's Sergio Perez.
In a one-stop race, Hamilton was forced to pit twice for fresh tyres and despite charging through the field on two occasions - collecting the fastest lap of the race - he could only finish ninth.
With Red Bull's Sebastian Vettel clinching back-to-back wins, and the 32nd of his career overall, Hamilton trails the 26-year-old German by 81 points with 175 available.
Hamilton's immediate reaction to his title chances after stepping out of the car was fully understandable as he said: "It was a disaster of a weekend and obviously that's that for the championship.
"I'm ninth and we should have been much further ahead, so I'm very disappointed with myself."
Just over an hour later, and on greater reflection, Hamilton offered a different viewpoint and is refusing to throw in the towel just yet.
"When I got out of the car I was angry and definitely thought that would be it," said Hamilton.
"But I've been back with my engineers and I'm not going to give up.
"I basically need to win every race, which is the tallest order ever, but I can do nothing but try."
Hamilton still appreciates, however, the mountainous task he faces, adding: "You think of winning every race anyway, but when you're up against a wall it's difficult to do that.
"I hope that moving on to these next few races we'll have a better chance and we progress into next year with an even better chance.
"We'll keep pushing, we're a good team and I do feel we can beat them (Red Bull) in some races moving forward, so fingers crossed.
"But then even if I win every race and he finishes second it is impossible."
Hamilton knows his woes began in qualifying when he could only claim 12th after making a mistake on his first run in the second session that broke the floor of his car.
On his second attempt he was blocked by former friend Adrian Sutil in his Force India, so it is no wonder his immediate mood post-race was negative.
Explaining his anger, Hamilton said: "Just within myself.
"After qualifying I handled it probably the best I've ever done.
"I was angry, like I always am, but I got over it way, way faster than I ever have.
"I turned it into a positive and so I arrived at the track energised and excited.
"I felt really good in the race, pushed, drove harder than ever and I really felt like I had nothing left in my heart at the end of it.
"But I was angry because it sucks when you do all that work and you only make up three places and get two points.
"That's the way it goes and we'll improve for the next races. We've got a competitive car, we'll get back ahead of the Ferraris, and I believe we can do that from here on."