For the 26th time in his McLaren career, but for the first time in the Brazilian Grand Prix, Hamilton will start from pole, leaving title rivals Sebastian Vettel and Fernando Alonso in his wake in fourth and eighth.
The 27-year-old, who now has one more day in the car before joining Mercedes next season on a three-year contract, spearheads McLaren's 62nd front-row lockout as he will have Jenson Button alongside him for company.
After clinching victory in last Sunday's United States Grand Prix, Hamilton is currently bowing out of McLaren on a remarkable high, with the chance now for back-to-back wins.
"It's been a good weekend so far, and I'm grateful to be able to put the car on the front row," said Hamilton.
"To have a one-two with Jenson, that's a fantastic job by the team.
"I'm grateful for all the opportunities the team have given me, and hopefully we can turn it into a positive."
The one variable, however, is the weather as rain is forecast - and lots of it, not just the odd shower hitting the circuit as was the case half an hour before qualifying which did not have much impact.
"We don't know what the hell is going to happen tomorrow [Sunday]," added Hamilton.
"The weather is going to be tricky, it's going to make it more of a lottery.
"I don't mind driving in the rain. I love it, and here in Brazil it's quite a special race when it rains.
"But we'll have to wait and see, make sure we get our tyre pressures right, brake temperatures correct and try and steer clear of any big puddles.
"We've put ourselves in a good position, so we'll work together as a team, and we'll make sure we do absolutely everything to get the top result."
Given the front-row performance, with Button beaten by 0.055secs to clinch his highest Interlagos grid slot, he dropped a broad hint he is unhappy to be seeing Hamilton depart.
"I'm very happy to be on the front row because my last couple of qualifying sessions have been a bit tricky," said Button.
"To both be on the front row for Lewis' last grand prix with the team...the team is in great shape, and it's a pity things have to change, but things do change."
Looking ahead to fighting with Hamilton in the race, but mindful of the weather forecast, Button added: "We're there to win the grand prix, the same as every other driver.
"That's the aim for both of us, and we'll see what we can do. The car seems to be working very well in the dry, our long run pace is pretty good.
"But there is a massive chance of rain tomorrow [Sunday] and that just throws it up in the air for us, which is quite exciting.
"But for two people (Vettel and Alonso), their stress levels are going to be through the roof.
"For us in starting near the front, it's hopefully going to be a very exciting race.
"We just have to hope the rain level is okay for us to actually race, which is always the worry here at Interlagos."