The Banbury-based marque had previously brought a car home no higher than 14th on six previous occasions ahead of the Singapore Grand Prix.
But under the lights of the Marina Bay Street Circuit, and at the end of a full two-hour race, Timo Glock finished 12th, his highest placing since the Singapore event three years ago.
Crucially, it means with six races remaining Marussia are 10th in the constructors' championship, which would bring with it much-needed financial rewards if they can hang on.
Lowdon, who is also president of the team, said: "It was great to get a result like that.
"Above all it was a reward for all the hard work and effort that has gone in by everyone back at Banbury who have done a great job putting improvements on the car.
"What we're finding now is we are competitive with the cars around us, and yet they're running with KERS (power-boost system) and we're not, so that bodes well for the rest of the season.
"For everyone, we all know how difficult this game is, and often the work of the guys at the back of the grid is not often seen, but it's as intense as if you're fighting for the championship.
"We obviously want to finish as high as we can, and that means top 10, which will mean a massive difference to us in terms of financial reward, so it is really, really important.
"It is also important we focus on the next races and we hang on to what we have."
Although Marussia have yet to score a point in more than 50 races since their arrival in F1 at the start of 2010 - the same with HRT and Caterham - Lowdon is convinced they are closing in on the feat.
Next year, in particular, Marussia will have KERS on their cars for the first time.
"We're knocking on the door now," said Lowdon with regard to breaking their points duck.
"We're still working harder on development and we're very hopeful we will continue to improve in the next few races.
"None of the new teams are there on straight pace yet, we're still relying on something happening in front, but the gap is closing.
"So we're really pleased with the progress being made."