The Enstone-based team's celebrations of their 500th grands prix turned sour around Monaco as early practice and qualifying pace suggested they would be the ones to make it six from six.
Instead, Romain Grosjean crashed out before the first corner and Kimi Raikkonen could only finish ninth behind Red Bull's Mark Webber.
It has since been a case of picking up the pieces for Boullier ahead of next weekend's Canadian Grand Prix.
"Yes, we are coming off the back of a disappointing weekend in Monaco, but we've shrugged off worse setbacks than that," said Boullier.
"Put simply, we didn't achieve the results we wanted, or the results it looked like we should have had.
"It's difficult to achieve a good result if one car doesn't make it to the first corner, and that's what happened to Romain.
"It was a racing incident, but that doesn't make it any easier for us to stomach as it was clear he had good pace all weekend.
"Kimi never quite got everything hooked up, and in the race he was unable to push as he struggled for grip.
"We can't get too hung up on this. It was one weekend in 20, and hopefully we can deliver better in the remaining 14 races."
Next up is Canada, a potential lottery of a grand prix given the proliferation of safety cars over the years, notably last season when there were five as torrential rain led to the longest race in F1 history.
Asked if Lotus could make it seven different winners this season, Boullier replied: "Let's hope so.
"Both Kimi and Romain are capable of winning and the car has shown race winning pace.
"Winning a grand prix is not the easiest thing in the world to achieve however, and I don't imagine we'll have a different winner for every race this year.
"A pattern should begin to emerge before too long.
"Now we're looking forward to Montreal. It's the first low downforce track of the season where the car should be strong.
"Our 500th race may not have been one of our best, but I hope the 501st is."