Not since 2004 have drivers from the same team claimed the top two spots in the standings when Michael Schumacher won the last of his seven world titles, beating Ferrari team-mate Rubens Barrichello.
At present, Vettel requires just a point from the final five grands prix, starting in Japan on Sunday, for back-to-back titles, whilst Webber is embroiled in a four-way scrap for second.
"All of us want to see Mark get a victory before the end of the year, and we want to see him achieve the runner-up spot," Horner said.
"If we could convert both titles, and with both drivers at the top of the drivers' championship, that for us would be an absolutely perfect year."
Horner has warned, though, that despite the fact Webber has not won for 21 races stretching back to last season's Hungarian Grand Prix, he will not be given an easy ride.
With Vettel's title all but assured, there will be no instance of the 35-year-old being waved through to take the chequered flag.
"Nothing will change, absolutely nothing. We will adopt the same approach, with them free to race," added Horner.
"The most important thing, however, is to close out the job in the drivers' championship, which is where the prestige sits.
"But if you ask any member of a team which is the more important championship I think up and down the pitlane they will probably say the constructors'.
"It's because that's what they are measured on, and that's what they are rewarded on as well."
Red Bull are also seeking to retain the constructors' title, although a double-whammy this weekend appears a long shot.
They are currently 138 points clear of McLaren and need a 172-point cushion coming out of the race at Suzuka.
"Theoretically it (winning the constructors') is unlikely this weekend," said Horner, who has celebrated Vettel wins in Japan in the last two years.
"But the most important thing is to try and outscore our opponents and we've got a good track record here, it would be great to build on that, on the results of 2009 and 2010."