Trumping Rossi will be easier said than done though as the Italian maestro has triumphed at the German GP six times in his illustrious career.
After an indifferent start to the season Lorenzo has been in top form of late, winning four of the last five races, with a third-place finish at last month's Dutch TT ending a four-race winning streak.
With Rossi having triumphed at Assen, he extended his lead atop the standings to 10 points, a lead Lorenzo is determined to vut.
"In theory Sachsenring is a worse track for us than Assen," he told reporters. "It never suited the Yamaha perfectly in the past so it's a very challenging circuit. I have never won in Germany, so I'm keen to get on the top step at least once. You never know, maybe it could happen this season because it's been a bit strange.
"I love Assen but this year something changed and I didn't find the perfect set up to be more competitive. During the race I struggled more than I expected but we understood how to solve it for the future."
Lorenzo recorded four consecutive second-place finishes at the German GP from 2009 to 2012, and will be looking to go one better this weekend.
"Sachsenring is a good racetrack with a nice atmosphere and a lot of fans," he said. "In the past I was close to winning a couple of times but I never did it.
"This year our bike's performance is good so I think we can achieve higher goals than in the recent years."