Orlando were four points down heading into the final stanza but stepped up to the challenge as they outscored the Lakers 40-26 to claim victory.
Arron Afflalo top-scored with 30 points for Orlando, with Kobe Bryant topping him with 34 points in a losing cause.
The New York Knicks lit up Madison Square Garden with their third win in a row - a 106-99 success over the Phoenix Suns.
Carmelo Anthony led scoring with 34 points, while Raymond Felton was strong in support with 23 points, seven assists and no turnovers.
Marcin Gortat was the Suns' standout with for 18 points and 10 rebounds.