Iestyn Harris' men will take on the French at The Glyndwr University Racecourse Stadium in Wrexham on Saturday, June 16, the same day as England's opening game against the Exiles at St Helens.
There are no club fixtures that weekend so both countries will be able to field their strongest teams, although Wales will not call on their Australian-based players.
It will be Wales' first mid-season international for 11 years and their first meeting with France since October 2010 when a late Lloyd White penalty gave them a 12-11 win in the European Cup in Albi to earn a place in the 2011 Four Nations Series.
"To be able to put on a mid-season Test shows a bit of progression to where we've come as we've not been in the position to do that in years gone by," said Harris.
"Hopefully this will increase to two or three in years to follow.
"It's going to be more difficult for us as there are a good number of our squad playing rugby league in Australia and we won't be able to call on them for this match.
"But this means that a number of other players will get the opportunity to play and prove that they are good enough to be in the squad for the end of the year.
"It's a progression game for us. Can we compete against a very strong French side with a couple of numbers down?
"It's an important game for us to see where we've come as a squad. It will be an interesting game."
France expect to have a new coach in place in time for the mid-season game, having opted not to renew the contract of Bobbie Goulding at the end of last season.
The international will be the culmination of a week of rugby league in Wrexham, with Glyndwr University hosting the annual British and Irish Student international tournament between Wales, England, Scotland and Ireland from June 11.
"It's going to be a big week for Wrexham and for Wales," said Harris.
"We want more and more people wanting to play and watch rugby league in Wales. To have the Student Home Nations there is fantastic too."
Wales and France will also meet at the end of the season in a triangular tournament involving England.
Wales meet the French in Perpignan on the weekend of October 20-21 and host England in Wrexham a week later. The final will be on the weekend of November 10-11.