Bubba Watson lost to Luke Donald 2&1
Donald replied to Watson's opening 14-foot birdie putt with a six-footer, went one ahead when the Masters champion three-putted the next and two-up after a brilliant approach to four feet at the fourth.
Donald birdied the 11th and when Watson missed a six-footer to bogey the 12th the gap was four. Even when the Chicago-based Donald hit into the water on 13 he got a half in bogeys, but after he missed a five-foot chance to finish it off with an eagle at the next Watson chipped dead at the 15th and chipped in on the 16th.
Both were for wins, but sensing a chance to grab a dramatic half he went long on 17 and Donald's superb bunker shot meant he had to chip in again. He could not.
Webb Simpson lost to Ian Poulter 2 holes
Saturday star Poulter chipped in on one, but Simpson saved a half from 15 feet and moved two up when the unbeaten Englishman bogeyed the second and fourth.
A bunker shot to three feet halved the deficit at the long fifth, Simpson was in the trees for another bogey at the 617-yard seventh and shanked his tee shot on the next, but he birdied the par five 10th to get his nose in front again.
Poulter's birdie on 12 levelled it again and they shared the next four before Simpson failed to get up and down from sand on the short 17th. Poulter drove right down the last, but managed to get his ball over the trees onto the green and won for his fourth straight victory. With that Europe were level 10-10.
Keegan Bradley lost to Rory McIlroy 2&1
Relieved to make the tee in time after needing a police escort, McIlroy was conceded the fourth when unbeaten debutant Bradley bogeyed. Both birdied the long fifth before the world number one chipped in on six to move two in front and then completed a front nine 32 with another birdie at the ninth.
Bradley had birdied the short eighth, however, so he started for home two down and cut that to one with a birdie on 10 before McIlroy salvaged a half with a brilliant up and down at the next.
The American, seeking his fourth straight win, levelled on 12 with a par, but McIlroy birdied the 15th with a superb bunker shot and the 16th with an even better pitch. Bradley had to make a 25-footer to stay alive on the next, but it drifted wide and Europe were only 10-9 down.
Phil Mickelson lost to Justin Rose 1 hole
Rose, who beat the four-time major champion in the 2008 singles, holed from 15 feet at the first, hit his tee shot to four feet on the next and did not have to putt after Mickelson went in the lake.
America's record cap-holder, winner of his first three games, was level by the fifth, but in a see-saw battle Rose was conceded an eagle on the seventh after a brilliant fairway wood approach, lost the eighth to a birdie and then replied by almost holing his second to the ninth.
One up as a result - and out in 32 like McIlroy just in front of him and Lawrie behind - Rose lost the 11th and 14th to birdies, but in an unbelievable finish holed from 40 feet at 17 and 14 feet on the last to make it 11-11. Europe had won the top five games.
Brandt Snedeker lost to Paul Lawrie 5&3
Lawrie had lost both his fourball games this week, managing just four birdies in 32 holes, but certainly saved his best till last as he thrashed a man who had won more than 11 million US dollars in the FedEx Cup just seven days earlier.
The 43-year-old Scot, making his first Cup appearance since 1999, chipped in from over the back of the fourth green for birdie and then holed from just eight feet for an eagle three on the fifth. Another birdie on the ninth took him out in four under and three up, although Snedeker did hit back with a birdie on the 10th to reduce the deficit.
However, Snedeker then gifted Lawrie the next three holes with consecutive bogeys and despite losing the 14th to a birdie, the former Open champion closed the door with a superb pitch to the 15th which eventually brought a concession from his opponent.
Dustin Johnson bt Nicolas Colsaerts 3&2
Colsaerts had been breathtaking in carding eight birdies and an eagle to carry Lee Westwood to victory on the opening day, but had struggled to find the same form on the greens in two subsequent defeats. The Belgian got off to a bad start with a bogey at the first but Johnson repaid the favour on the fourth.
Three birdies in a row from the American were only good enough for a one-hole advantage before Colsaerts got back on level terms with a birdie on the ninth, but the key moment came on the next. On the green in two and set to lead in the match for the first time, Colsaerts four-putted to card a bogey six and lose the hole, and it was no surprise when he bogeyed the next as well.
To his credit Colsaerts refused to buckle and got back on level terms, but Johnson birdied the 14th and 15th and a bogey from Colsaerts on the 16th sealed his fate.
Zach Johnson bt Graeme McDowell 2&1
McDowell had secured the winning point in the final singles match at Celtic Manor two years ago, but was not in the same sort of form at Medinah, losing two of his three matches with McIlroy before being rested for Saturday's fourballs.
The Northern Irishman got off to a terrible start against Johnson, making a bogey at the first and second and losing the third to a birdie to find himself three down. A birdie on the fourth reduced the deficit but a bogey six on the seventh halted the momentum. McDowell was never going to throw in the towel and birdied the ninth to be two down at the turn, but that was the closest he could get.
The 13th was halved with bogey fours and the steady Johnson closed the door with four straight pars to put his side 12-11 ahead.
Jim Furyk lost to Sergio Garcia 1 hole
Furyk had been a wild card selection of US captain Davis Love, but was only used twice before Sunday with one win and one defeat alongside Brandt Snedeker, although both matches were against McIlroy and McDowell and both were decided on the 18th.
There was never more than one hole in it against Garcia, who led for the only time in the match with a birdie on the second, but bogeyed the third to hand the advantage straight back. Another Garcia bogey on the eighth saw him go behind, but a birdie on the ninth got the Spaniard back on level terms.
A run of birdie-bogey-birdie from Furyk saw the American one up with four to play, but he then missed from 15ft for par - after taking an eternity to line up the putt - on the 17th to see the match level going up the 18th. And when another par putt on the last went narrowly wide, Garcia had won the last two holes to claim a vital victory and put Europe 13-12 ahead.
Jason Dufner bt Peter Hanson two up
The unflappable Dufner started superbly and four birdies in the first eight holes helped put him four up.
Hanson responded by winning the 10th with a birdie and Dufner then missed a short putt for a half at the 11th. He recovered his composure to restore a two-hole lead with a 40ft putt on 13, only to drop back again at the next.
Dufner drove the 15th green to help put him back two ahead but gave Hanson a sniff again by overshooting the 17th green from the bunker. Hanson sensed an unlikely half at the last but even after Dufner misread a long putt, he could not convert from the back of the green.
Matt Kuchar lost to Lee Westwood 3&2
Westwood never trailed but it was not until the 12th when he started to take a decisive grip as Kuchar missed a par putt to fall behind.
Westwood doubled his advantage at the next and, although Kuchar holed a long putt for a half at the 14th, a great birdie at the par-four 15th gave the European a three-hole lead.
The match was settled at the 16th. Westwood lipped out with his first attempt to secure victory but then followed up from three feet.
Steve Stricker lost to Martin Kaymer 1 hole
A birdie two at the second gave Stricker an early advantage but he was unable to pull clear and a bogey at the sixth allowed Kaymer back level.
Kaymer holed a long birdie putt at the ninth to take the lead for the first time but Stricker pulled back all square at the next. The German led again after the 12th but put his tee shot at the 13th into the water.
His superb birdie putt on the 14th gave him the advantage again but he squandered a chance to double his lead on 15 and it swung back all square.
Stricker's overhit chip and missed putt at the 17th guaranteed Kaymer at least a point and - by now knowing the cup was on the line - he held his nerve to hole out from five feet at the 18th after both players had initially badly missed.
The point took Europe to 14 overall and ensured they would retain the trophy.
Tiger Woods halved with Francesco Molinari
Molinari seized an early advantage by winning the second and third holes but then missed a putt to move three up at the fourth, a hole Woods ended up winning.
That proved the start of Woods' recovery and the match was all square again by the sixth. Molinari's birdie at the 10th saw the Italian regain the initiative but he missed a chance to double his lead at the 11th and Woods won the 12th and 13th to move ahead.
Woods let the advantage slip as he hit a bunker at the 14th and Molinari holed from 10 feet. Woods went back in front after Molinari chipped well past the 17th hole but the American missed a regulation par putt for victory at the last and had to settle for half a point.