Dustin Johnson had emerged as the most likely threat to overnight leader Snedeker, but the erratic Ryder Cup player racked up a triple-bogey seven at the penultimate hole to clear the way for his fellow American.
And despite finding sand off the final tee, the Nashville resident duly completed a regulation par to finish two under for the day and 16 under for the tournament, following his superb 63 yesterday.
Birdies at the second and seventh were partially offset by a bogey at the sixth, but it was a solid front nine for Snedeker. And he repeated the pattern after the turn to compete victory, earning a pay day of 1.008million US dollars (£655,000).
Johnson got a shot back at the last, his fifth birdie of the round, to share second place on 13 under and was left wondering what might have been.
Alongside him were Matt Kuchar - a third member of the US Ryder Cup team beaten at Medinah, who was two shots off Snedeker's overnight lead - plus William McGirt, whose 68 was the best round among the leading contenders, and Kuchar's playing partner Jason Bohn.
Three more United States players - John Merrick, Roberto Castro and Mark Wilson - were at 12 under, with the leading non-American, Australia's Aaron Baddeley, a further shot back alongside Jim Furyk and Patrick Reed.
Sweden's David Lingmerth, playing with Snedeker after a 65 yesterday left him one off the overnight lead, shot 75 to slip back to 10 under alongside Kyle Stanley, Rory Sabbatini and England's Greg Owen.